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Pictures of the Day CH320M/CH328M Fall 2012

The Importance of -S-S- Bonds in Biochemistry
Beta-lactamase Lysozyme
Click on the pictures and you will see two animated GIFs of proteins that contain disulfide (-S-S-) bonds. In the above structures, the disulfide bonds are shown in green as space filling models, the rest of the protein structure is shown in a cartoon format in which the chain of the amino acids is shown as a helix (pink), loop reagion (thin white) or beta sheet (burnt organe). Both of these proteins also have a substrate analog bound to them (purple) that is shown for reference. The grenn covalent disulfide bonds provide a link between distant parts of the protein structure and thus serve to stablize the three-dimensional folded structure of the protein.